Produced by
the Royal New Zealand College of General Practitioners
Alcohol workshop:
screening, assessment and
management in general practice
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topic information
CME remaining work
Case Study
Phil: Physical effects of alcohol
Introduction and Aims
Alcohol related problems
Contributing factor
Physical complications of alcohol use
Physical consequences
Physical signs of alcohol abuse
Suggestive sign
GGT
GGT results
Other causes of abnormal liver enzymes
Elevated GGT
AST/ALT
Elevated AST/ALT
Giving feedback
About abnormal tests
Improvement in liver function tests
Rate of change
Other blood tests
MCV and other tests
GGT as a screening test
Sensitivity of GGT screening
Quick quiz
Quiz answers
The half-life of GGT is approximately 26 days, which means that GGT generally returns to normal over about a month of abstinence.
Some effect of abstinence or reduced consumption on GGT is likely within weeks.
Resumption of heavy drinking increases GGT within about 2 weeks.
AST and ALT return to normal more slowly, and recovery rates vary according to age, sex and degree of liver damage.
Measurements of AST and ALT are recommended about every 2-3 months in the follow-up of heavy drinkers.
For any individual, there is an indirect correlation between alcohol consumption and abnormal liver enzymes.
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